Extended Data Fig. 4: Mutation rates relative to blood cell types and split by signatures.
From: Sperm sequencing reveals extensive positive selection in the male germline
a,b, Substitutions (a) and indels (b) per diploid cell from blood NanoSeq relative to specific blood cell types13. c,d, Substitutions per haploid cell for sperm (c) and diploid cell for blood (d) split by signature contributions of SBS1, SBS5, and SBS19. a,b,c,d, Models are linear mixed regressions, with the central line showing the model fit and the shaded bands indicating 95% confidence intervals calculated by parametric bootstrapping. e, Ratio of age-corrected blood to sperm substitutions per diploid cell per year for mutations assigned to SBS1 and SBS5. Each dot corresponds to an individual with both a blood and sperm sample and where individuals had multiple timepoints the mean value of all timepoints in that tissue was used. Box plots show the median as center line, the 25th and 75th percentiles as box limits, and whiskers extending to the largest and smallest values within 1.5× the interquartile range from the limits from n = 57 biologically independent samples.
