Fig. 3: Conformational states of NCLX.

a, NCLX in matrix- and cytosol- facing conformations. The transport domains are represented by the surface, whereas the gate domain helices are shown as cylinders. b, Superposition of the transport domain in matrix- and cytosol- facing conformations. c, Superposition of the gate domain in matrix- and cytosol- facing conformations. d, Superposition of NCLX in matrix- and cytosol- facing conformations. The arrow indicates the direction of the movement of the gate domain from the matrix- to the cytosol-facing conformation. e, The slab view of NCLX in the matrix-facing conformation. f, The slab view of NCLX in a cytosol-facing conformation. Ca²⁺ is shown as a magenta sphere in e and f.