Extended Data Fig. 10: Neuronal circuit activity drives invasion of SCLC cells.
From: Neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis
a, Immunofluorescent images demonstrating cells expanding beyond the invasive edge of the tumor in SCLC brain allografts (GFP, green) of WT (left) or optogenetically stimulated ChR2 animals (right). Scale bar = 100 µm. b, Immunofluorescent images demonstrating increased tumor area in SCLC brain allografts of WT or ChR2 animals. Scale bar = 150 µm. c, Quantification of data in b, illustrating increased tumor spread from core after optogenetic stimulation (n = 7 WT, n = 8 ChR2 animals, p = 0.0267). Data are mean ± s.e.m for c. Analysis with two-tailed unpaired t-test for c. *P < 0.05.
