Extended Data Fig. 7: LRP8 selectively inhibits TBEV E-mediated infection.
a, Infection of Huh-7.5.1 cells with single-cycle JEV RVPs after pre-incubation with increasing amounts of LRP8-LA1-2-Fc, LRP8-LA1-Fc, or human IgG isotype control. Averages ± s.d. are shown from three independent experiments, n = 9, where n indicates the number of biologically independent samples. b, Infection of Huh-7.5.1 cells with TBEVHypr after pre-incubation with increasing amounts of LRP8-LA1-2-Fc. Averages ± s.d. are shown from three experiments, n = 6, where n indicates the number of biologically independent replicates. c, Infection of U-87 MG glioblastoma cells with TBEVSofjin after pre-incubation with decreasing amounts of LRP8-LA1-2-Fc. Averages ± s.d. are shown from three experiments, n = 6. n indicates the number of biologically independent samples. Comparisons are shown between cells infected with untreated and LRP8-incubated virus and were analysed by one-way ANOVA with Dunnett’s test: ****, P < 0.0001.
