Extended Data Fig. 5: Calculation of positive selection at the sample level.
From: Sex and smoking bias in the selection of somatic mutations in human bladder
a) dN/dS truncating values for RBM10 and TP53 in the dome of donors 04 and 09. All legends as defined in Fig. 2. The p-values are calculated using the Omega implementation of the dN/dS approach described in Supplementary Note 6, and appear in Supplementary Table 6. b) Landscape of the fraction of urothelium covered by driver mutations of each gene in the panel. The values of covered urothelium have been discretized. In most cases, the percentage of urothelium covered by driver mutations of each gene falls in the lowest categories. The right-hand graph shows stacked barplots with the distribution of samples in different categories of covered urothelium across genes. c) Agreement of the magnitude of dN/dS missense (top) and dN/dS truncating (bottom) calculated for all genes in the dome and trigone of donors 14, 04 and 23. R-squared (R²), Pearson’s correlation coefficient of the dN/dS values calculated for the dome and trigone samples from each donor. The p-values corresponding to the Pearson’s correlation coefficients are shown.
