Extended Data Fig. 7: Structural comparison between the intermediate and fully active states of mTOR.
From: Structural basis for mTORC1 activation on the lysosomal membrane
Structures are superimposed based on Rheb. a, A carton representation of the mTOR-Rheb-mLST8 subcomplex. The motion between intermediate and fully active states are indicated with lines that connect the backbone of both structures. The distance of the motion is labeled with a rainbow color. b, The soluble structure of mTORC1-Rheb is in between the conformational change of the intermediate and fully active states of mTORC1-Rheb on membrane. c, Only the fully active state contains the ordered loop in the backside of the ATP pocket. The ordered loop (904–920) is colored red.
