Extended Data Fig. 1: Comparison of HoxD regulatory landscapes in mammals and fishes.
From: Co-option of an ancestral cloacal regulatory landscape during digit evolution
a. Hoxd gene expression and regulation in mouse limb buds at E12.5. The HoxD cluster is flanked by two gene deserts, named according to their relative position (3’ or 5’) with respect to Hoxd gene orientation. The 3DOM regulatory landscape activates Hoxd4 to Hoxd11 in the proximal limb territory (green). The 5DOM activates Hoxd10 to Hoxd13 in the distal limb territory (blue). Schemes are based on ref. 15. b. Gene expression in fin buds at 40–60 hpf in the cognate zebrafish hoxda cluster. The fish cluster is also flanked by two gene deserts but their regulatory potentials are unknown (question marks). Fish hoxd9a to hoxd11a are expressed in the preaxial fin territory (purple) whereas hoxd11a to hoxd13a are expressed in a postaxial domain (orange). Schemes are inspired and WISH taken from13,14,16.
