Extended Data Fig. 5: Both e-Mac and non-e-Mac islet macrophages can uptake apoptotic β-cells.
From: Efferocytic remodelling of pancreatic islet macrophages by limited β-cell death
a. Representative confocal images of the pancreatic islets of NOD mice 12 h after STZ1-low or control vehicle treatment. Green – apoptotic cells (cleaved caspase-3, CC3), blue – nuclei (Hoechst), red – Gal-3, white – F4/80, yellow – insulin. Scale bars: 20 µm (left, whole-islet view); 2 µm (right, zoomed-in view). b. Expression of Mer-TK by islet macrophages in Mertkfl/fl/Cx3cr1cre/wt (Mertk cKO) and Mertkfl/fl/Cx3cr1wt/wt, C57BL/6 mice. Data are representative of N = 3 independent experiments. The diagrams in a were created in BioRender. Ravichandran, K. (2025) https://BioRender.com/lwltf25.
