Extended Data Fig. 8: Structural analysis of Sgl-bound MurJ.
From: Convergent MurJ flippase inhibition by phage lysis proteins
a, Comparison of the three Sgl-bound MurJ structures aligned to either the N- or the C-lobe. Sgls are not shown. b, Comparison of Sgl-bound EcMurJ to the outward TaMurJ structure. Dashed boxes highlight structural differences in TM2 and TM7. c, As in b, comparison of the inward closed EcMurJ (PDB: 6CC4), TaMurJ (PDB:6NC6), and AeMurJ (PDB:7WAW) structures. d, Structure-based multiple sequence alignment based on MurJ structures in c for TM2 and TM7 of MurJ using PROSMAL3D with ClustalX coloring for residues. Sequence differences in the G/A-E-G-A motif in TM2 are highlighted.
