Fig. 2: Contribution of CGR to metagenomic and SNP analyses.
From: 1,520 reference genomes from cultivated human gut bacteria enable functional microbiome analyses
a, The read mapping ratio of a previous metagenomic analysis (IGCR) was significantly improved by CGR (IGCR + CGR) in fecal samples from Chinese (n = 368, P = 6 × 10−78), American (n = 139, P = 2 × 10−17), Spanish (n = 320, P = 4 × 10−50) and Danish (n = 109, P = 4 × 10−17) individuals. The significance of improvement was determined by two-side Wilcoxon rank-sum test. IGCR, 3,449 reference genomes used in the IGC study6; CGR, 1,520 reference genomes generated in this study. Each box plot illustrates the estimated median (center line), upper and lower quartiles (box limits), 1.5 × interquartile range (whiskers), and outliers (points) of the read mapping ratio. b, Reference genomes for SNP analysis generated in previous study17 (IGCR, green) and current study (CGR, blue). The unclassified species of reference genomes in CGR are highlighted in violet.
