Fig. 4: Pan-genome analysis of 38 representative clusters.
From: 1,520 reference genomes from cultivated human gut bacteria enable functional microbiome analyses
a, The distribution of genes involved in butyrate biosynthesis pathway in the core genomes (pink) and dispensable genomes (cyan). The two pathways for butyrate biosynthesis from acetyl-CoA are shown below. The species with a complete butyrate biosynthesis pathway in the core genome and pan-genome are highlighted in pink and cyan, respectively. Thl, thiolase; Hdb, β-hydroxybutyryl-CoA dehydrogenase; Cro, crotonase; Bcd, butyryl-CoA dehydrogenase (including electron transfer protein α and β subunits); But, butyryl-CoA:acetate CoA transferase; Ptb, phosphate butyryltransferase; Buk, butyrate kinase. b, The distribution of ARGs in in the core genomes (pink) and dispensable genomes (cyan).
