Supplementary Figure 8: Specificity of ABE7.10 and Sniper ABE7.10.
From: Genome-wide target specificity of CRISPR RNA-guided adenine base editors
On- and off-target activity and specificity ratio when using ABE7.10 and Sniper ABE7.10 at the HPRT-exon8, HEK2, EphB4 and TYRO3 sites. The red and blue characters indicate the mismatched nucleotides and PAM sequences, respectively. The specificity ratio was calculated using the following formula: specificity of Sniper ABE7.10 (on-target frequency/off-target frequency)/ specificity of conventional ABE7.10 (on-target frequency/off-target frequency). Means ± s.e.m. were from three independent experiments.
