Supplementary Figure 9: Specificity of ABE7.10 depending on plasmid delivery or RNP delivery.
From: Genome-wide target specificity of CRISPR RNA-guided adenine base editors
On- and off-target activity and specificity ratio when delivering plasmid or RNP at the HPRT-exon6, HEK2, EphB4 and TYRO3 sites. The red and blue characters indicate the mismatched nucleotides and PAM sequences, respectively. The specificity ratio was calculated using the following formula: specificity of RNP delivery (on-target frequency/off-target frequency)/ specificity of plasmid delivery (on-target frequency/off-target frequency). Means ± s.e.m. were from three independent experiments.
