Supplementary Figure 9: Survival of low- and high-passage FVB iPSCs.
From: De novo mutations in mitochondrial DNA of iPSCs produce immunogenic neoepitopes in mice and humans
a, FVB mice received different cell amounts of autologous low-passage (P13) or high-passage (P38) iPSCs grafts injected into the thigh muscle and were followed for immune response and teratoma development. b, After 5 days, splenocytes were recovered for Elispot assays (mean ± s.d., quadruplicates of 6 animals per group, two-tailed Student’s t-test). c, Teratoma growth is depicted for every animal and the percentage of teratoma formation for each group is shown in a separate bar graph (n = 6 per cell amount and iPSC group).
