Supplementary Figure 13: Schematic of the 5-chloro-3-formylindole biosynthetic gene cluster in WAC5374. | Nature Biotechnology

Supplementary Figure 13: Schematic of the 5-chloro-3-formylindole biosynthetic gene cluster in WAC5374.

From: Hidden antibiotics in actinomycetes can be identified by inactivation of gene clusters for common antibiotics

Supplementary Figure 13

The NRPS encodes a tripeptide with at least one putative tryptophan when analyzed by AntiSMASH37. While deletion of the NRPS from WAC5374 ΔstrH had no effect on the production of 5-chloro-3-formylindole, deletion of the tryptophan halogenase abolished production and confirmed its role in biosynthesis.

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