Table 1 Mendelian error rates of n = 12 biologically independent sire/dam/offspring trios in four families

From: Genomic and phenotypic analyses of six offspring of a genome-edited hornless bull

Study group

Family

Sire

Dam

Offspring

N errors

Percentage per variant

Percentage per individual

Sequencing coverage (×)

Sire

Dam

Offspring

GH.H.

1

RCI002

RC.dam1

RC.calf1

169,672

1.2

0.4

20.2

17.5

20.1

RC.dam2

RC.calf2

158,736

1.1

0.4

20.2

18.8

19.5

RC.dam3

RC.calf3

126,192

0.9

0.3

20.2

25.9

22.9

RC.dam4

RC.calf4

143,283

1.0

0.3

20.2

19.8

21.3

RC.dam5

RC.calf5

174,909

1.2

0.4

20.2

20.7

16.5

RC.dam6

RC.calf6

137,177

1.0

0.3

20.2

18.7

26.7

H.H.

2

HH.sire1

HH.dam1

HH.calf1

125,899

0.9

0.3

17.4

20.6

21.4

3

HH.sire23

HH.dam2

HH.calf2

120,690

0.9

0.3

22.2

17.5

19.4

HH.dam3

HH.calf3

117,590

0.8

0.3

22.2

19.9

19.6

Ho.H.

4

HO1

Ho1.dam1

Ho1.calf1

141,404

1.0

0.3

19.6

20.0

21.7

Ho1.dam2

Ho1.calf2

143,436

1.0

0.3

19.6

24.9

18.8

Ho1.dam3

Ho1.calf3

184,300

1.3

0.4

19.6

15.9

17.2

  1. N errors, number of Mendelian errors (offspring not concordant with parental genotypes) when comparing 14,084,653 variants, unfiltered for low genotyping rate or minor allele frequency; percentage per variant, percentage probability of a Mendelian error for each biallelic variant in a trio; percentage per individual, percentage probability of a Mendelian error for each biallelic variant in each individual. WGS coverage is shown for each individual.
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