Supplementary Figure 3: Nanopore signal processing with STRique.
From: Analysis of short tandem repeat expansions and their methylation state with nanopore sequencing
a) Signal alignment detecting prefix and suffix flanking the repeat using a capped distance score function and a semi-global alignment. A compound profile HMM of prefix, a single repeat and the suffix sequence assigns either prefix, repeat or suffix label to each signal value. Repeat counts are obtained through dummy states between repeat and suffix. b) Nanopore signal profile HMM with normal distributed match state and uniform distributed insertion state emission probabilities.
