Supplementary Figure 12: Integration of co-regulation scores with STRING (https://string-db.org).
From: Co-regulation map of the human proteome enables identification of protein functions
A typical protein - protein association network in STRING, containing the Arp2/3 complex and tropomyosin 3, both of which are involved in actin cytoskeleton regulation. Network edges are colour-coded by the type of evidence available for the association. Protein co-regulation information is embedded in the gene coexpression channel. The channel view shows the channel-specific STRING score, a re-calibrated version of our co-regulation score. It also contains a pre-computed link to www.proteomeHD.net, which uses the first protein as ProteomeHD query and highlights the second protein in the results. If more than one protein isoform is available in ProteomeHD, STRING will link to the alphabetically first isoform, which is generally the main one. The link also contains a cut-off setting to match the ProteomeHD cut-off to the equivalent one selected by the user in STRING. In cases where both mRNA coexpression and protein co-regulation evidence is available for an association, their relative contribution to the STRING coexpression score is indicated (shown here as point 3).
