Supplementary Figure 12: PDTs present in PhosphoSitePlus as a function of EBDT parameter tuning and relationship between number of compounds in kinase inhibitor fingerprint and PDT size. | Nature Biotechnology

Supplementary Figure 12: PDTs present in PhosphoSitePlus as a function of EBDT parameter tuning and relationship between number of compounds in kinase inhibitor fingerprint and PDT size.

From: Reconstructing kinase network topologies from phosphoproteomics data reveals cancer-associated rewiring

Supplementary Figure 12

Number of phosphosites in PDTs matched that were present in PhosphoSitePlus for the same kinase as a function of tuning the EBDT algorithm with different probability thresholds (a) or site-kinase inhibition ratio thresholds (b). (c) Number of phosphosites found to be PDTs of given kinases as a function of number of compounds in kinase inhibitors fingerprints for the respective kinase. Total number of PDTs in dataset is 6,206. Boxplots show median, interquartile ranges, and ranges. Outliers are shown as individual data points.

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