Fig. 4: Polishing assembled genomes.
From: Nanopore sequencing and the Shasta toolkit enable efficient de novo assembly of eleven human genomes
a, Balanced error rates for the four methods on HG00733 and CHM13. b, Row-normalized heatmaps describing the predicted run lengths (x axis) given true run lengths (y axis) for four steps of the pipeline on HG00733. Guppy v.2.3.3 was generated from 3.7 Gb of RLE sequence. Shasta, MarginPolish and HELEN were generated from whole assemblies aligned to their respective truth sequences. c, Error rates for MarginPolish and HELEN on four assemblies. d, Average runtime and cost.
