Supplementary Fig. 8: Time dynamics of the frequency of SDGD^dsx as function of female fitness.

Time dynamics of the frequency of SDGD^dsx transgenic individuals in the population as a function of W/D (where D represent the SDGD allele and W the wild-type allele) female fitness (w_WD,xx), as predicted by the deterministic discrete-generation model at 25% initial allelic frequency. The graph shows the frequency of SDGD heterozygote males and females as a proportion of the male (or female) population, with other parameter estimates and baseline values given in Supp Table 2 (SDGD male fitness = 0.854; m (sex distortion) = 0.93). The predicted outcome at high W/D female fitness is elimination of the population, and at lower fitness, an intermediate equilibrium with W, R and D alleles. The result (black line) for the experimental estimate for female SDGD heterozygote fitness, w_WD,xx = 0.627, is in a parameter region where even a small (positive) change leads to a prediction of population elimination instead of suppression.