Fig. 5: Differences between moderate and critical COVID-19 severity are attributed to non-resident macrophage over-expression of cytokines/chemokines and extravasation. | Nature Biotechnology

Fig. 5: Differences between moderate and critical COVID-19 severity are attributed to non-resident macrophage over-expression of cytokines/chemokines and extravasation.

From: COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis

Fig. 5

Dot plots depicting the average expression of specific cytokines/chemokines and extravasation cascade genes of patients with moderate (BIH-CoV-12) and critical (BIH-CoV-02, BIH-CoV-06 and BIH-CoV-07) COVID-19, ordered by severity as indicated by different clinical features. The sampling days per patient are reflected by ‘days after onset of symptoms’. Expression levels are color coded; the percentage of cells expressing the respective gene is size coded. Significant changes for each time point in the patients with critical COVID-19 versus an average of the three time points of the patient with modertate COVID-19 (BIH-CoV-12) (left panel) are marked by a red circle (Benjamini–Hochberg adjusted two-tailed, negative-binomial P < 0.05). Rel. Exp., relative gene expression; Pct. Exp., percentage of cells expressing the gene.

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