Extended Data Fig. 4: Interaction of chemokines with their respective receptors comparing controls, to moderate and critical COVID-19 cases. | Nature Biotechnology

Extended Data Fig. 4: Interaction of chemokines with their respective receptors comparing controls, to moderate and critical COVID-19 cases.

From: COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis

Extended Data Fig. 4

Expression of chemokines and their respective receptors in the different cellular subpopulations is depicted by dot plots. Connecting lines represent receptor/ligand pairs as obtained from the molecular cell atlas of the human lung65 complemented by literature research. Expression levels are color coded while the percentage of cells expressing the gene are depicted by the different dot sizes. Red circles show significance (Benjamini-Hochberg adjusted two-tailed negative-binomial p-value < 0.05) of expression when comparing critical and moderate patients (critical panels) or moderate patients and controls (moderate panels) as calculated by a two-sided significance test. (n = 5 moderate and 6 critical COVID-19 patients, 10 samples each). Nasopharyngeal swab samples were used in this analysis: n = 5 control samples, n = 14 moderate COVID-19 samples, and n = 13 critical COVID-19 samples. Rel. Exp. = relative gene expression, Pct. Exp. = percentage of cells expressing the gene.

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