Extended Data Fig. 1: On-target activities of nCas9 controls, ABE variants and more CBE variants tested for C-to-G editing in HEK293T cells. | Nature Biotechnology

Extended Data Fig. 1: On-target activities of nCas9 controls, ABE variants and more CBE variants tested for C-to-G editing in HEK293T cells.

From: CRISPR C-to-G base editors for inducing targeted DNA transversions in human cells

Extended Data Fig. 1

Bar plots showing the on-target DNA base editing frequencies induced by nCas9 negative controls, ABE and ABE variants and other CBE variants with seven gRNAs in HEK293T cells. Editing frequencies of three independent replicates (n = 3) at each base are displayed side-by-side. Arrowheads indicate cytosines showing C-to-G edits by CGBE1.

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