Extended Data Fig. 5: Aggregated distribution of C-to-G editing frequencies across protospacer with CGBE1 and miniCGBE1 in HEK293T cells.
From: CRISPR C-to-G base editors for inducing targeted DNA transversions in human cells
a, b, Dot and box plots representing the aggregate distribution of C-to-G (yellow) editing frequencies per nucleotide across the entire protospacer from experiments performed with CGBE1 (a) and miniCGBE1 (b) with all 48 tested gRNAs. Boxes span the interquartile range (IQR; 25th to 75th percentile), horizontal lines indicate the median (50th percentile), and whiskers extend to ± 1.5 × IQR. Data points in plots represent full range of values plotted. Single dots represent individual replicates. The graphs were derived from the data shown in Fig. 3a, b (n = 4 independent replicates per site), and Supplementary Fig. 3a (n = 3 independent replicates per site).
