Extended Data Fig. 4: OncoSigRF predictions are highly enriched in oncogenic KRASMut dependencies.
From: Oncoprotein-specific molecular interaction maps (SigMaps) for cancer network analyses
a, GSEA of KRASMut synthetic lethal partners25 (blue lines, N = 216) and the top 500 OncoSigRF LUAD-specific KRAS SigMap predictions obtained by training on a modified PGSS for which the intersection with the synthetic lethal set was removed. Inset is the GSEA using all OncoSigRF predictions obtained in this way, where the ranking is OncoSigRF score. Enrichment analysis was performed with the aREA (analytic Rank-based Enrichment Analysis) algorithm10. b, Enrichment of the protein resistance-signature to ERK inhibitor SCH77298428 (blue lines, N = 24) within OncoSigRF LUAD-specific KRAS SigMap predictions10. c, Enrichment of proteins involved in response to Reactive Oxygen Species (GO:0000302)8,29 (blue lines, N = 276) within OncoSigRF LUAD-specific KRAS SigMap predictions10.
