Extended Data Fig. 6: OncoSigRF SigMaps for hypermutated oncoproteins are retrospectively validated.
From: Oncoprotein-specific molecular interaction maps (SigMaps) for cancer network analyses
a, Pairwise overlap of established pathway proteins (left) and the OncoSigRF LUAD-specific SigMaps (FPR ≤ 0.01, right) for the ten hyper-mutated oncoproteins (names of columns and rows). Percent overlap is color-coded according to the scale at top. b, SigMap predictions are highly enriched in 600 EGFR-centric network proteins52 (p = 2.3 ×10−43). Enrichment analysis was performed with the aREA (analytic Rank-based Enrichment Analysis) algorithm10. c, Box plots of the OncoSigRF LUAD-specific EGFR SigMap scores for two subsets of the curated EGFR pathway proteins from Astsaturov et al:52 those identified as EGFR synthetic lethal partners (red, N = 58) and those not identified as synthetic lethal (grey, N = 542). The p-value (2 ×10−4) was calculated using Welch’s two sample t-test.
