Fig. 2: Total metabolic changes with changes in disease severity from T1 to T2. | Nature Biotechnology

Fig. 2: Total metabolic changes with changes in disease severity from T1 to T2.

From: Integrated analysis of plasma and single immune cells uncovers metabolic changes in individuals with COVID-19

Fig. 2

a, Metabolic pathway activities for all PBMCs pooled together that are significantly correlated with WHO score by two-sided Spearman’s rank correlation (P < 0.05; labeled on right). Exact P values are listed in Supplementary Table 7. b, UMAP for dimensional reduction of scRNA-seq data of peripheral immune cells collected from each individual. UMAP was performed separately using only genes included in metabolic pathways (left) and using all genes (right). c, Changes in metabolic pathway activities over time (from T1 to T2) per peripheral immune cell type for individuals whose WHO scores worsened, improved or remained stable. A relative activity of 0 indicates no change in the activity of a metabolic pathway from T1 to T2.

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