Extended Data Fig. 10: GBM nuORFs.
From: Unannotated proteins expand the MHC-I-restricted immunopeptidome in cancer
a. Some nuORFs predicted to be GBM-specific are translated in non-cancerous samples. RNA-seq and Ribo-seq expression (log2(TPM+1)) of nuORFs predicted to be GBM-specific (y axis) in published primary GBM and non-cancer brain samples and differentiating hESCs (x axis). b. nuORFs are detected in published GBM and non-cancerous MHC I immunopeptidomes. Number of MS-detected nuORFs (x axis) of different types (y axis) in GBM (right) and non-cancerous brain (left) samples. c. LC-MS/MS spectrum of a peptide from SOX2-OT nuORF.
