Extended Data Fig. 9: Histology taken from swine dosed multiple times with L-SOMAs over three days. | Nature Biotechnology

Extended Data Fig. 9: Histology taken from swine dosed multiple times with L-SOMAs over three days.

From: Oral delivery of systemic monoclonal antibodies, peptides and small molecules using gastric auto-injectors

Extended Data Fig. 9

(a–c) Three samples were collected according to standard histopathological procedures representing the (a) cardia, the (b) fundic, and the (c) pyloric region. No treatment related findings were observed in these standard samples in any of the three swine. (d) Histology from a minimal focal lesion from the fundic region of one of the three swine. The image shows an acute minimal erosion with sloughing of epithelial cells and peripheral acute hemorrhage. This injury is most likely a mechanical trauma caused by the endoscope when dosing the animal and is not a direct effect of the intended L-SOMA dosing. (e) Zoomed in image of “d”. (a-c: Scale Bar = 500 µm; d: Scale Bar = 1 mm.; e: Scale Bar = 250 µm).

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