Extended Data Fig. 8: Molecular modelling of PHLPP2N1186Y-specific pMHC-TCRs interactions.
From: Sensitive identification of neoantigens and cognate TCRs in human solid tumors
Modelled structures of the three PHLPP2N1186Y- specific TCRs (TCR-A, -B, and -C, Supplementary Table 6) showing detailed predicted interactions with a cognate pMHC complex. TCRα ribbon is colored in light green, with relevant interacting residues displayed in sticks. Atoms are colored according to the atom types, with the exception of carbon atoms that are colored in light green. TCRβ is colored in orange, with relevant interacting residues displayed in sticks and atoms colored according to the atom types, with carbon colored in orange. MHC (HLA-A*01:01) is colored in light blue, with residues displayed in sticks and atoms colored according to the atom types, with carbon colored in light blue. The peptide is shown in grey sticks and atoms colored according to the atom types and carbon colored in grey. Residues are labelled in black.
