Extended Data Fig. 5: An independent cohort replicates glucose uptake associations.

a, Correlation coefficients for the common sites that passed filtering to test for correlation to glucose uptake in both studies (significant regulation and quantification in ≥ 50% of the samples, discovery cohort: Pearson’s correlation, validation cohort: Kendall’s rank correlation) are plotted. Green points are reported mTOR/p70S6K substrates. b, Phosphosites that passed filtering to correlate with glucose uptake (regulated, quantified ≥ 50% samples) were ordered by -log₁₀p of their correlation to glucose uptake, their ANOVA significance, or their magnitude fold change. Enrichment was calculated with Kolmogorov-Smirnov test with empirical p-values. c, Enrichment of Gene Ontology biological processes in the glucose uptake-associated phosphosites, calculated by Fisher’s exact test, filtered for pathways with BH p_adj < 0.05. d, Enrichment of kinase substrates amongst phosphosites positively correlated with glucose uptake (p_adj < 0.05, r > 0, Fisher’s exact test). e, Glucose uptake Kendall’s rank correlation coefficients and BH p_adj of phosphosites grouped by kinase. Asterisks indicate Kolmogorov-Smirnov test empirical p-value < 0.05. Correlations and Kolmogorov-Smirnov tests were two-sided. Fisher’s exact tests were one-sided.