Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

RNA THERAPEUTICS

RNA delivery with a human virus-like particle

Nature Biotechnology volume 39, pages 1514–1515 (2021)Cite this article

Subjects

RNA cargo is transferred into cultured cells using a fully human delivery system.

Access through your institution
Buy or subscribe

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Delivery of mRNA cargo by virus-like particles derived from endogenous retroelements.

References

  1. Segel, M. et al. Science 373, 882–889 (2021).

    Article  CAS  Google Scholar 

  2. Feschotte, C. & Gilbert, C. Nat. Rev. Genet. 13, 283–296 (2012).

    Article  CAS  Google Scholar 

  3. Ono, R. et al. Nat. Genet. 38, 101–106 (2006).

    Article  CAS  Google Scholar 

  4. Baden, L. R. et al. N. Engl. J. Med. 384, 403–416 (2021).

    Article  CAS  Google Scholar 

  5. Polack, F. P. et al. N. Engl. J. Med. 383, 2603–2615 (2020).

    Article  CAS  Google Scholar 

  6. Rosenblum, D., Gutkin, A., Dammes, N. & Peer, D. Adv. Drug Deliv. Rev. 154-155, 176–186 (2020).

    Article  CAS  Google Scholar 

  7. Kedmi, R. et al. Nat. Nanotechnol. 13, 214–219 (2018).

    Article  CAS  Google Scholar 

  8. Veiga, N. et al. J. Control. Release 313, 33–41 (2019).

    Article  CAS  Google Scholar 

  9. Rosenblum, D. et al. Sci. Adv. 6, eabc9450 (2020).

    Article  CAS  Google Scholar 

  10. Dammes, N. et al. Nat. Nanotechnol. 16, 1030–1038 (2021).

    Article  CAS  Google Scholar 

Download references

Author information

Author notes

  1. These authors contributed equally: Anna Gutkin, Daniel Rosenblum.

Authors and Affiliations

  1. Laboratory of Precision Nanomedicine, The Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel

    Anna Gutkin & Dan Peer

  2. Department of Materials Sciences and Engineering, Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel

    Anna Gutkin & Dan Peer

  3. Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv, Israel

    Anna Gutkin & Dan Peer

  4. Department of Pathology, New York University Langone Health, New York, New York, USA

    Daniel Rosenblum

Authors
  1. Anna Gutkin
    View author publications

    Search author on:PubMed Google Scholar

  2. Daniel Rosenblum
    View author publications

    Search author on:PubMed Google Scholar

  3. Dan Peer
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to Dan Peer.

Ethics declarations

Competing interests

D.P. receives licensing fees (to patents on which he was an inventor) from, invested in, consults (or on scientific advisory boards or boards of directors) for, lectured (and received a fee) or conducts sponsored research at TAU for the following entities: ART Biosciences, BioNTech RNA Pharmaceuticals, EPM Inc., Earli Inc., lmpetis Biosciences, Kernal Biologics, Newphase Ltd, NLC Pharma Ltd, NeoVac Ltd, Roche, SirTLabs Corporation and Teva Pharmaceuticals Inc. All other authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gutkin, A., Rosenblum, D. & Peer, D. RNA delivery with a human virus-like particle. Nat Biotechnol 39, 1514–1515 (2021). https://doi.org/10.1038/s41587-021-01124-x

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/s41587-021-01124-x

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research