Extended Data Fig. 1: Additional characterization of CLAMPs.
From: Conformation-locking antibodies for the discovery and characterization of KRAS inhibitors
(a) Structures of KRASG12C covalent small molecules. (b) Representative SPR traces of 1A5 and 2H11 CLAMPs against KRASG12C-GDP+GNE-1952 and KRASG12C-GDP. (c) Epitope binning results indicate that group 1 and group 2 antibodies bind two overlapping epitopes.
