Extended Data Fig. 8: Additional quality controls.
From: Massively parallel phenotyping of coding variants in cancer with Perturb-seq
a,b. Spearman correlation between sc-eVIP scores and genes most highly correlated with sc-eVIP scores (x axis) for TP53 (a) and KRAS (b). c. Significance (y axis) of two-sided t-tests comparing the expression of each gene (dots) in bulk RNA-seq samples with WT KRAS and either G12C (left) or G12V (right). The genes are grouped by their gene programs (x axis) as defined in our current single-cell study. Values represent signed -log10 (p-values), adjusted for multiple testing using the Benjamini-Hochberg procedure.
