Extended Data Fig. 6: SCAVENGE analysis of inherited ALL predisposition.
From: Variant to function mapping at single-cell resolution through network propagation
a, The seed cells (top) and per cell SCAVENGE TRS (bottom) of ALL risk genetic predisposition are demonstrated in the UMAP embeddings of hematopoiesis scATAC-seq dataset 2. The corresponding cell type labels are shown in Extended Data Fig. 4b. b, Correlations of SCAVENGE TRS and TF motif enrichment score. Scatter plots show TFs (left) including PAX5 and EBF1 that are positively correlated with ALL risk predisposition and TFs (right) including NFE2 and RUNX2 that are negatively correlated with ALL risk predisposition. The dots are colored by TRS. Spearman correlation is calculated between SCAVENGE TRSs and TF motif enrichment scores across all the cells of B-cell development trajectory.
