Extended Data Fig. 5: Analysis of TEG behavior and killing properties.
From: Uncovering the mode of action of engineered T cells in patient cancer organoids
(a) Quantification of the first action and second action of CD4+ and CD8+ TEGs after they engaged with an organoid. (n = 3 independent experiments). Hypergeometric test was used to analyze cell type enrichment in each category. ‘Kills multiple cells’ p < 0.0001; ‘Kills one cell’ p = 0.000015; ‘No killing’ p= 0.0018. (b) Quantification of the number of cells killed in a sequence by CD8+TEGs in time. (n = 3 independent experiments). (c) Quantification of the time it takes to kill one 13 T tumor cell for CD4+ TEGs and CD8+ TEGs (n = 3 independent experiments).
