Extended Data Fig. 8: CNV detection performance as a function of tumor cell fraction. | Nature Biotechnology

Extended Data Fig. 8: CNV detection performance as a function of tumor cell fraction.

From: Haplotype-aware analysis of somatic copy number variations from single-cell transcriptomes

Extended Data Fig. 8

At each tumor cell fraction, tumor cells were subsampled and mixed with randomly sampled normal cells at the corresponding proportion. Precision, recall and F1 scores were calculated based on the detected segments from scRNA-seq data and the ground truth copy number profiles (from WGS) in 5 multiple myeloma samples. For Numbat, two methods are compared: pseudobulk joint HMM (Numbat-HMM) and iterative optimization (Numbat-iterative) with no minimum pseudobulk size limit. a, Performance for all event types (amplification, deletion, and CNLoH). b, Performance for amplifications. c, Performance for deletions.

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