Extended Data Fig. 10: Single-cell copy number profile and phylogeny reconstructed by Numbat (TNBC and ATC). | Nature Biotechnology

Extended Data Fig. 10: Single-cell copy number profile and phylogeny reconstructed by Numbat (TNBC and ATC).

From: Haplotype-aware analysis of somatic copy number variations from single-cell transcriptomes

Extended Data Fig. 10

Branch lengths correspond to the number of CNV events. Blue dashed line separates predicted tumor and normal cells. Confident subclones are highlighted and marked by red dashed rectangles. The vertical bar on the left of each panel shows cell type ground truth. In TNBC5 and ATC2, the second vertical bar on the left of the panel shows variant allele frequency of a clone-associated mitochondrial mutation. For ATC2, results from the subsampled dataset (including aneuploid cells and 50 randomly sampled normal cells) are shown. In ATC5, some tumor cells were likely mis-annotated as normal in the original annotation.

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