Extended Data Fig. 8: Gene regulatory programs during mouse organogenesis.
From: Solid-phase capture and profiling of open chromatin by spatial ATAC
a. Visium expression, spatial ATAC gene activity and regulatory element accessibility at E12.5 for CNS/Forebrain markers Pax6 and Foxg1. The respective linked regulatory element is shown in gray. b. Visium expression, spatial ATAC gene activity and regulatory element accessibility for Mesenchyme/Limb markers Rxra and Twist2. The respective linked regulatory element is shown in gray. c. Visium expression, spatial ATAC gene activity and regulatory element accessibility for liver markers Slc4a1 and Hba-a1. The respective linked regulatory element is shown in gray. Arrowheads point to clusters for which the regulatory element is most accessible. d. Motif enrichment rank plots for cluster-specific distal elements. Selected top non-redundant transcription factor motifs are highlighted. P values were determined by a one-sided hypergeometric test. Scale bars are 500 µm.
