Extended Data Fig. 10: Multimodal integration of single-cell RNA-seq with spatial ATAC and Visium on breast cancer sections.
From: Solid-phase capture and profiling of open chromatin by spatial ATAC
a. Clusters based on original or DCA denoised peak counts. b. Heatmap displaying the percentage of spots being assigned to the clusters obtained from original or denoised spatial ATAC data. c. Visualization of peak accessibility scores before and after denoising on one example section. d. Prediction scores from scRNA-seq signatures in spatial ATAC clusters reveal cell composition differences across clusters. e. Prediction scores from scRNA-seq signatures in Visium clusters. Scale bars are 500 µm.
