Extended Data Fig. 7: Guide-dependent off-target evaluation of CBE-T.
From: Improved cytosine base editors generated from TadA variants
Color map of % maximum on-target C·G to T·A conversion at genomic sites and % maximum C·G to T·A conversion at their corresponding off-target sites in HEK293T cells transfected with mRNA encoding editor (or control) plus synthetic sgRNA at saturating conditions. Median values were derived from n = 3 independent biological replicates performed on different days.
