Extended Data Fig. 5: Genome-wide statistics on cell-type-specific prediction.

a, The distribution of interaction intensity by insulation correlation (Pearson) between the experimental Hi-C matrices of IMR-90 and GM12878. Dotted lines denote the filtering criteria in selecting representative loci with cell-type specificity. Colormap indicates the corresponding Spearman correlation coefficient (ρ). b–c, Pearson’s r (left) and Spearman’s ρ (right) between prediction (row) and experimental data (column) for different cell types with insulation score (b) and observed/expected score (c) as metrics. Diagonal entries denote the metrics of prediction and Hi-C in the same cell type without filtering for cell-type-specific regions. The scores were calculated based on the differentially structured loci defined in Fig. 3. d, The distribution of interaction intensity selected for structurally conserved regions between two cell types, similar to a. e–f, Same as b–c but for the structurally conserved loci across different cell types.