Extended Data Fig. 4: Tumor-specific ECF values of subtype marker genes in BRCA samples for which clinical subtype information was available.
From: Single-cell mapping of combinatorial target antigens for CAR switches using logic gates
The boxplot shows the ECF status of three markers, containing ERBB2, ESR1, and PGR, for all subtypes (ERpositive: n = 11, HER2-positive: n = 8, HER2 and ER double positive: n = 4, TNBC: n = 12): TNBC, Triple-negative breast cancer; ‘+‘ means ‘positive’. Average values of ECFs for ERBB2, ESR1, and PGR, were 0.33 ± 0.15 (s.d.), 0.68 ± 0.15 (s.d), and 0.29 ± 0.18 (s.d.) in ER-positive subtype while HER2-positive subtype showed 0.86 ± 0.19 (s.d.), 0.18 ± 0.3 (s.d.), and 0.01 ± 0.01 (s.d.), respectively. In the case of HER2+ ER+, average values were 0.47 ± 0.19 (s.d.), 0.25 ± 0.23 (s.d.), and 0.06 ± 0.05 (s.d.), and the TNBC subtype showed 0.24 ± 0.14 (s.d), 0.05 ± 0.12 (s.d.), and 0.05 ± 0.15 (s.d.), for ERBB2, ESR1, and PGR, respectively. Data in the box plot represent the first quartile (25%), median (center), and third quartile (75%) with minimum and maximum values. Black points indicate the outliers.
