Extended Data Fig. 2: DisP-seq signals and DisP islands in different chromatin states defined by ChromHMM.
From: DisP-seq reveals the genome-wide functional organization of DNA-associated disordered proteins
a-f, Representative examples of DisP-seq peaks and associated chromatin marks in different chromatin states defined by ChromHMM: Promoter (a), Active enhancer (b), Weak enhancer (c), Quiescent (d), repressed polycomb (PC) (e) and heterochromatin (f). DisP-seq peaks are highlighted in light gray. g,h, Box plot showing levels of different histone modifications in active enhancers (g) and weak enhancers (h) with or without DisP-seq signals (n = 2 biologically independent experiments). Median value is shown as a line within the boxplot, which spans from the 25th to 75th percentiles. Whiskers indicate a 1.5× inter-quartile range. i, Pie chart depicting the fraction of DisP islands with EWS-FLI1 signals in SKNMC cells. j, Percentage of peaks of DisP islands in each ChromHMM category. k, Venn diagram depicting the overlap between DisP islands and Super enhancers in SKNMC cells.
