Extended Data Fig. 7: Sensor editing continues over time, independent of selection.
From: High-throughput evaluation of genetic variants with prime editing sensor libraries
a, Log2 fold change in pegRNA correct editing percentage relative to Day 4, with pegRNAs split into groups by LFC in pegRNA counts at the final time-point. Data shown for pegRNAs ≥ 1% editing and with ≥ 100 sensor reads at all time-points in the untreated condition. LFC calculated using MAGeCK from the median values across n = 3 biologically independent samples. In all boxplots, boxes indicate the median and interquartile range (IQR) for each sample with whiskers extending 1.5 × IQR past the upper and lower quartiles, with outliers indicated with circles. b, Same as (a), but with fold change in editing normalized to Day 16. c, Same as (a), but for the Nutlin-treated condition. d, Same as (b), but for the Nutlin-treated condition.
