Extended Data Fig. 10: Heterogeneity of off-target sites. | Nature Biotechnology

Extended Data Fig. 10: Heterogeneity of off-target sites.

From: Tracking-seq reveals the heterogeneity of off-target effects in CRISPR–Cas9-mediated genome editing

Extended Data Fig. 10

a, Scatter plots showing the correlation between Track scores and indel rates of 4 cell types at 7 differential off-target sites. b, The wild-type genome sequences of NIH3T3 cells, AML12 cells, mHSPCs, and mESCs around tested off-target sites. Dots in the bar charts indicate biological replicates. c, Indel rates and Track scores of the off-target sites Dif-04 to Dif-07 in four cell types and their ATAC-seq, H3K9me3 ChIP-seq, and H3K27ac ChIP-seq signals. Dots in the bar charts indicate biological replicates. d, Enrichment of epigenetic profiles around off-target sites of Pcsk9-gP+G in NIH3T3 cells, AML12 cells, mHSPCs, and mESCs.

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