Extended Data Fig. 2: Single-cell data analysis to define the GvHD filter gene set. | Nature Biotechnology

Extended Data Fig. 2: Single-cell data analysis to define the GvHD filter gene set.

From: Systematic identification of minor histocompatibility antigens predicts outcomes of allogeneic hematopoietic cell transplantation

Extended Data Fig. 2

a, Summary of the single-cell datasets used, related to the following organs target of GvHD: oral mucosa, lacrimal gland (eye), skin, liver, colon (GI) and lung. For each organ analyzed, the number of datasets and their accession numbers are shown, together with the total number of cells after standard single-cell data QC analysis, as well as after removal of immune cells. The ID of the second lung dataset has been abbreviated for ease of visualization, but the full identifier is reported in c legend. b, UMAP plots showing clustering of the resident cell types for each organ. Note that for ‘eye’, the dataset includes both primary cells and organoids (derived from ductal cells), which were both analyzed. c, Violin plots of lineage-defining markers for each cell type across the different organ datasets. d, UMAP plots showing the relative contribution of individual datasets, for those organs with 2 available. Vasc., vascular; Lymph., lymphatic; KC, keratinocyte; LSEC, liver sinusoidal endothelial cells; CT, crypt top.

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