Extended Data Fig. 1: PIONEER provides high-quality interfaces for the whole proteome. | Nature Biotechnology

Extended Data Fig. 1: PIONEER provides high-quality interfaces for the whole proteome.

From: A structurally informed human protein–protein interactome reveals proteome-wide perturbations caused by disease mutations

Extended Data Fig. 1

a, Workflow for compiling interactome PIONEER. The interfaces calculated from experimentally determined co-crystal structures or homology models are primarily used, the remaining unresolved interactions are predicted by PIONEER. b, Percentage of CAPRI decoys having a given average PIONEER prediction score at interfaces. Percentages are plotted along the y axis for 4 classes of CAPRI models. The total number of models in each class is indicated in the text in the figure. c, Fraction of interactions disrupted by random population variants in PIONEER-predicted and known interfaces. The error bar denotes standard error for the binomial distribution. Significance was determined by two-sided z-test. The n numbers are shown in Supplementary Table 6. d, Enrichment of disease-associated mutations in PIONEER-predicted and known interfaces. The error bar denotes standard error for the log odds ratio. Significance was determined by two-sided z-test. The n numbers are shown in Supplementary Table 7. e, Enrichment of population variants in PIONEER-predicted and known interfaces. The error bar denotes standard error for the log odds ratio. The n numbers are shown in Supplementary Table 8.

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