Extended Data Fig. 2: Pharmacogenomic landscape identified by the PIONEER-predicted interactome network.

a, Drug responses evaluated by oncoPPIs in the PDX models. Effect size was quantified by Cohen’s d statistic using the difference between two means divided by a pooled s.d. for the data. Significance was determined by ANOVA adjusted by Benjamini-Hochberg method. b, Circos plot displaying drug responses evaluated by putative PIONEER-predicted oncoPPIs harboring a statistically significant excess number of missense mutations at PPI interfaces, following a binomial distribution across selected anti-cancer therapeutic agents in cancer cell lines. Each node denotes a specific oncoPPI. Node size denotes significance determined by ANOVA. Effect size was quantified by Cohen’s d statistic using the difference between two means divided by a pooled s.d. for the data. Node color denotes three different types of PPIs: (1) PDB: Red; (2) HM: Blue; and (3) PIONEER: Green. ‘HM’ represents homolog models. c, Highlighted examples of drug responses. Data are represented as a box plot with an underlaid violin plot in which the middle line is the median, the lower and upper edges of the box are the first and third quartiles, the whiskers represent IQR × 1.5, and the dots are outlier points. Significance was determined by ANOVA. The n numbers are shown in Supplementary Table 16.